Endocrine Abstracts

Our previous data showed that histological markers of the X-zone in mice adrenal (fetal zone in human adrenal) were still present in adult males and postpartum SF1/SOCS3 KO females. This change led to a distinct distribution of lipid droplets along the adrenal cortex and a blunted ACTH-induced corticosterone secretion in SF1/SOCS3 KO mice. Here we have examined the morphological and functional adrenals of SF1/SOCS3KO male mice adrenals at 3, 8 and 15 weeks through histochemica...

Changes in the composition of the extracellular matrix (ECM) induce different cell signaling in normal tissues and in pathological conditions. ECM alteration in the adrenal microenvironment may contribute to both the development and function of adrenal gland. The adrenal gland consists of a cortex, with three concentric zones, glomerulosa (ZG), fasciculata (ZF) and reticularis (ZR), and the medulla (M), surrounded by a capsule. Here, we describe the differences among the ECM s...